Journal
SEMINARS IN HEMATOLOGY
Volume 57, Issue 4, Pages 185-193Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.seminhematol.2020.11.003
Keywords
Natural killer cell; Innate memory; Cancer immunotherapy; Cytokine; Cytokine receptor; Cytokine-induced memory-like
Categories
Funding
- Howard Hughes Medical Institute
- National Institutes of Health (NIH) [T32HL00708843, K12CA167540]
- SPORE in Leukemia [P50CA171963, R01CA205239]
- Siteman Cancer Center [P30CA091842]
- V Foundation for Cancer Research
- Children's Discovery Institute (CDI) at WUSM
- Jamie Erin Follicular Lymphoma Research Fund
Ask authors/readers for more resources
Natural killer (NK) cells are cytotoxic innate lymphoid cells that protect the host from infection and mediate anti-tumor responses. Classically considered part of the innate immune system, NK cells were previously thought to not possess the specificity or enhanced recall responses associated with adaptive T and B lymphocytes. However, a large body of work has transformed these long-held divisions between innate and adaptive immunity; NK cell memory and memory-like responses are clearly established after hapten exposure, viral infection, and combined cytokine activation. These advances come with opportunities to translate innate NK cell recall responses into the clinic as cancer immunotherapy. Here, we review our current understanding of the heterogeneity of memory and memory-like NK cell responses, with distinct formation, molecular biology, and memory type functions. We elaborate on cytokine-induced memory like NK cells and highlight their application as adoptive immunotherapy for cancer, and as a platform for engineering optimal NK cell anti-tumor responses. (C) 2020 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available