Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 21, Issue 23, Pages 7193-7196Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.09.068
Keywords
Synthesis; Glycosyl hydrazine; Glycosyl hydrazone; Antitumor activity; Antifungal activity; Toxicity
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Funding
- National Natural Science Foundation of China [21102173]
- China Scholarship Council (CSC) [[2008]3019]
- Japan Society for the Promotion of Science (JSPS) [P10100]
- Grants-in-Aid for Scientific Research [10F00100] Funding Source: KAKEN
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Assuming that the water solubility of our previous hydrazone derivatives would improve after modification with sugars while keeping or modulating their notable biological activities, we designed and synthesized some glycosyl hydrazine and hydrazone derivatives. Bioassay results indicated that the antitumor activity of our previously prepared hydrazones reduced or disappeared after modification with sugars. On the contrary, some glycosyl derivatives displayed much better antifungal activity against selected fungi. Obviously, a small sugar can change the biological activity of hydrazones significantly. (C) 2011 Elsevier Ltd. All rights reserved.
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