Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 21, Issue 2, Pages 710-714Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.11.124
Keywords
Carbonic anhydrase; Coral; Stylophora pistillata; Anion inhibitor; Sulfonamide; Carbon fixation
Categories
Funding
- European Union
- Italian FIRB [MIUR/FIRB RBNE03PX83_001]
- Government of Principality of Monaco
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The catalytic activity and the inhibition of a new coral carbonic anhydrase (CA, EC 4.2.1.1), from the scleractinian coral Stylophora pistillata, STPCA-2, has been investigated. STPCA-2 has high catalytic activity for the physiological reaction being less sensitive to anion and sulfonamide inhibitors compared to STPCA, a coral enzyme previously described. The best STPCA-2 anion inhibitors were sulfamide, sulfamic acid, phenylboronic acid, and phenylarsonic acid (K(I)s of 5.7-67.2 mu M) whereas the best sulfonamide inhibitors were acetazolamide and dichlorophenamide (KIs of 74-79 nM). Because this discriminatory effect between these two coral CAs, sulfonamides may be useful to better understand the physiological role of STPCA and STPCA-2 in corals and biomineralization processes. (C) 2010 Elsevier Ltd. All rights reserved.
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