Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 21, Issue 8, Pages 2313-2315Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.02.095
Keywords
Streptomyces; Quinoline; Structure elucidation; Cytotoxicity
Categories
Funding
- National Key Project for Basic Research [2010CB126102]
- National Natural Science Foundation of China [30771427, 31000884]
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A new quinoline derivative, methyl 8-(3-methoxy-3-methylbutyl)-2-methylquinoline-4-carboxylate (1), was isolated from the endophytic strain Streptomyces sp. neau50, and the structure was elucidated by extensive spectroscopic analysis. Compound 1 showed cytotoxicity against human lung adenocarcinoma cell line A549 with an IC50 value of 29.3 mu gmL (1). (C) 2011 Elsevier Ltd. All rights reserved.
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