Journal
FUNCTION
Volume 1, Issue 2, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/function/zqaa017
Keywords
tubular proteinuria; Dent disease; endocytosis; recycling; megalin; cubilin
Categories
Funding
- NIH [F31 DK121394, R01 DK125049]
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Dent disease (DD) is a rare kidney disorder caused by mutations in the Cl-/H+ exchanger ClC-5. Extensive physiologic characterization of the transporter has begun to illuminate its role in endosomal ion homeostasis. Nevertheless, we have yet to understand how loss of ClC-5 function in the kidney proximal tubule impairs membrane traffic of megalin and cubilin receptors to cause the low molecular weight proteinuria characteristic of DD. This review identifies open questions that remain to be answered, evaluates the current literature addressing these questions, and suggests new testable models that may link loss of ClC-5 function to tubular proteinuria in DD.
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