Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 36, Issue 3, Pages 513-538Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X15617172
Keywords
Astrocytes; brain edema; capillaries; cerebrospinal fluid; endothelium
Categories
Funding
- National Institute of Neurological Disorders and Stroke (NINDS) [NS060801, NS061808]
- National Heart, Lung and Blood Institute [HL082517]
- NINDS [NS061934, NS072501]
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Advancements in molecular biology have led to a greater understanding of the individual proteins responsible for generating cerebral edema. In large part, the study of cerebral edema is the study of maladaptive ion transport. Following acute CNS injury, cells of the neurovascular unit, particularly brain endothelial cells and astrocytes, undergo a program of pre-and post-transcriptional changes in the activity of ion channels and transporters. These changes can result in maladaptive ion transport and the generation of abnormal osmotic forces that, ultimately, manifest as cerebral edema. This review discusses past models and current knowledge regarding the molecular and cellular pathophysiology of cerebral edema.
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