Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 21, Issue 1, Pages 125-129Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.11.057
Keywords
Dysoxylum hainanense; Triterpenoids; Structural elucidation; Antibacterial activity; Structure-activity relationship
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Funding
- National Natural Science Foundation [30701044, 21072203]
- Chinese Academy of Sciences [KSCX2-YW-R-117, KSCX2-YW-R-184)]
- National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program' of the People's Republic of China [2009ZX09301-001]
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Five new ring A-seco triterpenoids, dysoxyhainic acids F-J (1-5), along with a known ring A-seco triterpenoid koetjapic acid (6) were isolated from the twigs and leaves of Dysoxylum hainanense. Their structures were established on the basis of extensive spectroscopic analysis. Antimicrobial activity of all the compounds against fungi and bacteria were tested. Compounds 2-4 and 6 exhibited significant antimicrobial activity against Gram-positive bacteria, and the antibacterial SAR (structure-activity relationship) was also briefly discussed. (C) 2010 Elsevier Ltd. All rights reserved.
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