Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 35, Issue 6, Pages 883-887Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/jcbfm.2015.60
Keywords
hemodynamic; neurovascular coupling; pericytes; scar formation; stroke
Categories
Funding
- German Research Foundation [TRR43, FOR1336-2]
Ask authors/readers for more resources
Pericytes are mural cells with contractile properties. Here, we provide evidence that microvascular pericytes modulate cerebral blood flow in response to neuronal activity ('functional hyperemia'). Besides their role in neurovascular coupling, pericytes are responsive to brain damage. Cerebral ischemia is associated with constrictions and death of capillary pericytes, followed by fibrotic reorganization of the ischemic tissue.,The data suggest that precapillary arterioles and capillaries are major sites of hemodynamic regulation in the brain.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available