Journal
RSC ADVANCES
Volume 10, Issue 27, Pages 15794-15799Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ra01539c
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Funding
- Council of Scientific and Industrial Research, CSIR [80(0085)/16/EMR-II]
- CSIR-IICT [IICT/Pubs./2019/315]
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6-Exo-trig cyclization reaction through regioselective carbopalladation was demonstrated with N-(2-halobenzyl)-N-allylamines to furnish the corresponding C4-substituted tetrahydroisoquinoline derivatives. The scope of the reaction was extended to the synthesis of C4-quaternary tetrahydroisoquinoline derivatives also. The nature of the substituent on the olefin moiety dictates the course of the carbopalladation sequence. Regioselective carbopalladation is substantiated by performing the reaction with unsymmetrical diallylated amine substrates.
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