Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 21, Issue 1, Pages 267-270Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.11.020
Keywords
Marine sponge; Amphimedon sp.; 3-Alkylpyridine alkaloids; Pyrinodemins E and F
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
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Two new 3-alkylpyridine alkaloids, pyrinodemins E(1) and F(2), were isolated from an Okinawan marine sponge Amphimedon sp. and the structures of 1 and 2 were elucidated on the basis of spectroscopic data. Pyrinodemins E(1) and F(2) were novel 3-alkylpyridine alkaloids possessing a 4-(methoxyamino)piperidinone moiety and an indol-3-glyoxylamide moiety, respectively. Pyrinodemin E (1) showed cytotoxicity against P388 and L1210 murine leukemia cells. (C) 2010 Elsevier Ltd. All rights reserved.
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