Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 21, Issue 10, Pages 3084-3087Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.03.028
Keywords
Diindolyl ethylene; Nitroethane; Friedel-Crafts acylation; In vitro cytotoxic activity; MTS-PMS assay
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Funding
- CSIR, India
- CSIR [NWP 0033, IAP 0001]
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2,2'-Diphenyl-3,3'-diindolylethylene (DPDIE) derivatives 3a-g were regioselectively prepared in one pot from indoles 1a-g in the presence of Lewis acids and were subsequently evaluated for cytotoxic activity against human leukemic cell lines, U937 and K562. The most potent compound 3g exhibited IC50 of 13.0-17.0 mu M. (C) 2011 Elsevier Ltd. All rights reserved.
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