Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 36, Issue 3, Pages 576-580Publisher
NATURE PUBLISHING GROUP
DOI: 10.1177/0271678X15620434
Keywords
7 T magnetic resonance imaging; amyloid angiopathy; histology; microbleeds; perivascular spaces
Categories
Funding
- ZonMw (VIDI)
- Netherlands Organization for Health Research and Development [91711384]
- Netherlands Heart Foundation [2010 T073]
- NIH [R01AG047975, R01AG026484, P50AG005134]
- European Research Council under the European Union's Seventh Framework Programme (FP7)/ERC [337333]
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Perivascular spaces are an emerging marker of small vessel disease. Perivascular spaces in the centrum semiovale have been associated with cerebral amyloid angiopathy. However, a direct topographical relationship between dilated perivascular spaces and cerebral amyloid angiopathy severity has not been established. We examined this association using post-mortem magnetic resonance imaging in five cases with evidence of cerebral amyloid angiopathy pathology. Juxtacortical perivascular spaces dilation was evaluated on T2 images and related to cerebral amyloid angiopathy severity in overlying cortical areas on 34 tissue sections stained for Amyloid beta. Degree of perivascular spaces dilation was significantly associated with cerebral amyloid angiopathy severity (odds ratio = 3.3, 95% confidence interval 1.3-7.9, p = 0.011). Thus, dilated juxtacortical perivascular spaces are a promising neuroimaging marker of cerebral amyloid angiopathy severity.
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