Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 15, Pages 4416-4419Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.06.052
Keywords
Anti-HIV; beta-Carboline; 1-Formyl-beta-carboline; CEM-GFP cells
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Funding
- Department of Biotechnology, Ministry of Science and Technology, Government of India [BT/PR7020/Med/14/930/2005]
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A series of beta-carboline derivatives were synthesized by utilizing aromatization and chemoselective alkylation method recently reported from our laboratory. Synthesized derivatives were evaluated for anti-HIV activity in human CD4+ T cell line (CEM-GFP) infected with HIV-1 NL4.3 virus. 1-Formyl-beta-carboline-3-carbxylic acid methyl ester (15) showed inhibition of human immunodeficiency virus at IC50 = 2.9 mu M. (C) 2010 Elsevier Ltd. All rights reserved.
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