Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 66, Pages 9469-9472Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc03591b
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Funding
- National Natural Science Foundation of China [21871053, 21532001]
- Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang [2019R01005]
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A photoredox-catalyzed three-component reaction of aryldiazonium tetrafluoroborates with sodium metabisulfite and 2,2-difluoro enol silyl ethers is described. By using sodium metabisulfite as the source of sulfur dioxide, this method provides an elegant access to alpha,alpha-difluoro-beta-ketosulfones in moderate to good yields under mild conditions, and features a broad substrate scope and wide functional group tolerance. Both of the difluoromethyl group and sulfone moiety can be introduced in a single step. Based on the experimental results, a single-electron transfer pathway is proposed with the insertion of sulfur dioxide.
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