Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 3, Pages 1065-1069Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.12.035
Keywords
11 beta-Hydroxysteroid dehydrogenase 1; Cyclic sulfonamide; Diabetes; Inhibitor
Categories
Funding
- Center for Biological Modulators of the 21st Century Frontier RD Program
- Ministry of Education, Science and Technology, Korea
Ask authors/readers for more resources
A new series of cyclic sulfonamide derivatives was synthesized and evaluated for their ability to inhibit 11 beta-HSD1. Cyclic sulfonamides with phenylacetyl substituents at the 2-position showed nanomolar inhibitory activities. Among them, compound 4e exhibited a good in vitro inhibitory activity and selectivity toward human 11 beta-HSD2. (C) 2009 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
