Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 1, Pages 112-116Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.11.013
Keywords
Lck inhibitor; Kinase inhibitor
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We have identified a novel series of ring-fused pyrazole derivatives as lymphocyte-specific kinase (Lck) inhibitors. The most potent analogs exhibited good enzyme inhibitory activity (IC(50)s <1 nM) as well as excellent cellular activity against mixed lymphocyte reaction (MLR) (IC(50)s <1 nM). (C) 2009 Elsevier Ltd. All rights reserved.
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