Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 24, Pages 7365-7368Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.10.046
Keywords
Antiviral; Click chemistry; Nucleotides analogues; HCV
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Funding
- Comite Mixte Inter-universitaire Franco-Marocain Programme [MA/06/143]
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Preparation of several triazoloacyclic nucleoside phosphonates is described. The key step of the synthesis involves a copper(I)-catalysed azide-alkyne 1,3-dipolar cycloaddition between azidoalkylphosphonates and propargylated nucleobases. The antiviral properties of these new analogues have been evaluated and revealed interesting potencies. (C) 2010 Elsevier Ltd. All rights reserved.
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