Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 23, Pages 7064-7066Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.09.108
Keywords
Alzheimer diseases; Acetyl cholinesterase; AChE inhibitor; 1,3-Dipolar cycloaddition; Azomethine ylide
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Series of pyrolidine analogues were synthesized and examined as acetylcholinesterase (AChE) inhibitors. Among the compounds, compounds 4k and 6k were the most potent inhibitors of the series. Compound 4k, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC(50) 0.10 mu mol/L. Pyrolidine analogues might be potential acetyl cholinesterase agents for AD. (C) 2010 Elsevier Ltd. All rights reserved.
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