Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 30, Pages 4184-4187Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc01560a
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Funding
- National Natural Science Foundation of China (NSFC) [21677060]
- Zhejiang Provincial Natural Science Foundation of China [LQ19B050002]
- Program for Science and Technology of Jiaxing [2019AY11009]
- Student Research Training Program of Jiaxing University [CD8517193176]
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Here, a new strategy based on artificial multifunctional allostery (mFA) was explored to regulate the assembly of a DNA nanowire using circulating tumor DNA (ctDNA) as the initiator. Given its unique properties, the mFA-regulated versatile DNA nanowire was applied to engineer a single-step, amplified and dynamic biosensor for the quantitative analysis of ctDNA in serum samples with tunable sensitivity and selectivity.
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