4.7 Article

New fluorescent light-up quinoxalines differentiate between parallel and nonparallel G-quadruplex topologies using different excitation/emission channels

Journal

CHEMICAL COMMUNICATIONS
Volume 56, Issue 30, Pages 4168-4171

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc01242d

Keywords

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Funding

  1. National Natural Science Foundation of China [81803348]
  2. Natural Science Foundation of Guangdong Province [2018A030310580]
  3. Shenzhen Science and Technology Innovation Commission [JCYJ20170818141916158]
  4. Natural Science Research Project of Shenzhen University [000002110517]

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In this study, new fluorescent quinoxalines were developed as G4 topology-selective probes. Among them, the most promising one could light up parallel G4s at two separate excitation wavelengths, exhibiting dual-channel emission, and light up nonparallel G4s at one excitation wavelength, showing mono-channel emission.

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