4.7 Article

Construction of trifluoromethylated quaternary stereocenters via p-quinone methides

Journal

CHEMICAL COMMUNICATIONS
Volume 56, Issue 20, Pages 3031-3034

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc08936e

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Development of a new synthetic method for the construction of quaternary centers with a trifluoromethyl group was realized by way of 1,6-addition of various nucleophiles including active methylene compounds to highly reactive delta-trifluoromethylated p-quinone methides generated in situ from the corresponding tertiary carbonates with a catalytic amount of an appropriate base.

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