Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 35, Issue 3, Pages 367-370Publisher
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2014.211
Keywords
brain imaging; cortical mapping; intrinsic optical imaging; neurovascular coupling
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Funding
- National Institutes of Health [R01NS078223, P01NS080675, K25NS083754]
- Washington University's Imaging Science Pathway
- Washington University's Olin Fellowship
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Brain function can be assessed from resting-state functional connectivity (rs-fc) maps, most commonly created by analyzing the dynamics of cerebral hemoglobin concentration. Here, we develop the use of Laser Speckle Contrast Imaging (LSCI) for mapping rs-fc using cerebral blood flow (CBF) dynamics. Because LSCI is intrinsically noisy, we used spatial and temporal averaging to sufficiently raise the signal-to-noise ratio for observing robust functional networks. Although CBF-based rs-fc maps in healthy mice are qualitatively similar to simultaneously-acquired [HbO(2)]-based maps, some quantitative regional differences were observed. These combined flow/concentration maps might help clarify mechanisms involved in network disruption during disease.
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