Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 14, Pages 4156-4158Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.05.058
Keywords
MEK; Pyrrole; Oncology
Categories
Funding
- U.S. Department of Energy (DOE) [DE-AC02-05CH11231]
- Lawrence Berkeley National Laboratory
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A novel series of pyrrole inhibitors of MEK kinase has been developed using structure-based drug design. Optimization of the series led to the identification of potent inhibitors with good pharmaceutical properties. (C) 2010 Elsevier Ltd. All rights reserved.
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