Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 35, Issue 10, Pages 1547-1551Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/jcbfm.2015.180
Keywords
angiogenesis; endothelial progenitor cell; matrix metalloproteinase-9; neurorepair; stroke
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Funding
- Spanish Ministry of Health [CP09/00265]
- Spanish Instituto de Salud Carlos III [PI10/00694, PI13/01094]
- European Regional Development Fund
- Spanish Stroke Research Network INVICTUS [RD12/0014/00059]
- ERANET-NEURON program from the Spanish Ministerio de Economia y Competitividad [PRPPRI-PIMN EU-2011-1352]
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Endothelial progenitor cells (EPCs) are being investigated for advanced therapies, and matrix metalloproteinase 9 (MMP9) has an important role in stroke recovery. Our aim was to determine whether tissue MMP9 influences the EPC-induced angiogenesis after ischemia. Wild-type (WT) and MMP9-deficient mice (MMP9/KO) were subjected to cerebral ischemia and treated with vehicle or outgrowth EPCs. After 3 weeks, we observed an increase in the peri-infarct vessel density in WT animals but not in MMP9/KO mice; no differences were found in the vehicle-treated groups. Our data suggest that tissue MMP9 has a crucial role in EPC-induced vascular remodeling after stroke.
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