Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 13, Pages 3911-3915Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.05.017
Keywords
Fluorescence probe; Triarylphosphine; Mitochondria; Lipid peroxide
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Funding
- Grants-in-Aid for Scientific Research [22550087] Funding Source: KAKEN
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In this study, a new type of fluorescence probe, diphenylpyrenylphosphine- conjugated alkyltriphenyl-phosphonium iodide which was accumulated in mitochondria, has been synthesized. This probe was detected peroxide in living cell. Comparison of the reactivity toward several peroxide indicated that the probe was existed in mitochondrial membrane. Using this probe, generation of peroxide in mitochondria of living cell was successfully visualized. (c) 2010 Elsevier Ltd. All rights reserved.
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