Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 12, Pages 3658-3663Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.04.100
Keywords
Trichoderin; Trichoderma sp.; Aminolipopeptide; Anti-mycobacterial activity; Dormant; Tuberculosis
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Funding
- Helen Hay Whitney Foundation
- Hoh-ansha Foundation
- Uehara Memorial Foundation
- JSPS-South Africa (NRF)
- Ministry of Education, Culture, Sports, Science and Technology of Japan
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Three new aminolipopeptides, designated trichoderins A (1), A1 (2), and B (3), were isolated from a culture of marine sponge-derived fungus of Trichoderma sp. as anti-mycobacterial substances with activity against active and dormant bacilli. The chemical structures of trichoderins were determined on the basis of spectroscopic study. Trichoderins showed potent anti-mycobacterial activity against Mycobacterium smegmatis, Mycobacterium bovis BCG, and Mycobacterium tuberculosis H37Rv under standard aerobic growth conditions as well as dormancy-inducing hypoxic conditions, with MIC values in the range of 0.02-2.0 mu g/mL. (C) 2010 Elsevier Ltd. All rights reserved.
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