Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 23, Pages 6975-6977Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.09.130
Keywords
Malaria; Dihydroartemisinin; Quinoline; Hybrid; Dimer
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Funding
- National Research Foundation [Key International Science Capacity (KISC) Initiative]
- North-West University
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Novel artemisinin-quinoline hybrid-dimers were synthesized from dihydroartemisinin and different aminoquinolines at elevated temperatures (90-110 degrees C). All compounds were obtained as the beta-isomers and were tested against both chloroquine sensitive and resistant strains of Plasmodium falciparum. Hybrid-dimer 8 showed the highest antiplasmodial activity, inheriting the optimum chain length of three carbon atoms. (C) 2010 Elsevier Ltd. All rights reserved.
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