Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 12, Pages 3521-3525Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.04.138
Keywords
Bicyclo[3.3.0]octane derivatives; Dipeptidyl peptidase 4; Inhibitors; Oral glucose tolerance tests; Type 2 diabetes
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A series of novel bicyclo[3.3.0]octane derivatives have been synthesized and found to be dipeptidyl peptidase 4 (DPP-4) inhibitors. Compounds 10a and 10b demonstrate good efficacies in oral glucose tolerance tests. (C) 2010 Elsevier Ltd. All rights reserved.
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