4.5 Article

Hybrid liposomes inhibit the growth of Cholangiocarcinoma by induction of cell cycle arrest in G1 phase

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 12, Pages 3680-3682

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.04.091

Keywords

Hybrid liposomes; Cholangiocarcinoma; G(1) phase cell cycle arrest

Funding

  1. Ministry of Education, Science, Sports, and Culture (MEXT) of Japan [21107522, 20107007, 20360377, 21591209]
  2. Grants-in-Aid for Scientific Research [21107522, 21591209] Funding Source: KAKEN

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Specific accumulation and cell cycle arrest were observed in human cholangiocarcinoma cells by hybrid liposomes composed of 90 mol % L-alpha-dimyristoylphosphatidylcholine (DMPC) and 10 mol % polyoxyethylene(21)dodecyl ether (C-12(EO)(21)) without affecting normal cholangiocytes. (c) 2010 Elsevier Ltd. All rights reserved.

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