Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 3, Pages 1141-1144Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.12.011
Keywords
Transglutaminase inhibitor; Protein cross-link inhibitor; Alzheimer's disease; Huntington's disease; Parkinson's disease; Celiac disease
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Aryl beta-aminoethyl ketones were discovered as potent inhibitors of tissue transglutaminase. Heteroary-llike thiophene groups and N-benzyl N-t-butyl aminoethyl group are critical to the strong inhibitory activity of aryl beta-aminoethyl ketones. (C) 2009 Elsevier Ltd. All rights reserved.
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