Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 3, Pages 975-978Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.12.049
Keywords
MRSA; Antimicrobial agent; Aminoderivatized chitosans; Synegistic effect
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Funding
- Chosun University
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Two kinds of aminoethyl-chitosans (AEC), AEC90 and AEC50, which had degrees of deacetylation of 90% and 50%, respectively, were prepared and their synergistic effects in combination with beta-lactams including ampicillin, penicillin, and oxacillin against two standard methicillin-resistant Staphylococcus aureus (MRSA) strains and twelve clinical isolated MRSA strains were investigated. When AECs and beta-lactams were combined, synergistic effects were observed with fractional inhibitory concentration (FIC) indices of 0.252-0.508, and the MICs of beta-lactams in the presence of AECs were dramatically reduced. (c) 2009 Elsevier Ltd. All rights reserved.
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