Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 6, Pages 1869-1872Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.01.146
Keywords
TLR2 agonist; Water-soluble; Immunoadjuvant
Categories
Funding
- Universite de Strasbourg
- Centre National de la Recherche Scientifique (C.N.R.S.)
- Region Alsace
- ARC
- Ministere de la Recherche
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Four novel water-soluble lipid immunoadjuvants were designed, synthesized and characterized by MS and NMR. They all induce mouse dendritic cell maturation and B cell proliferation. We demonstrate that in spite of the chemical modification, the four compounds remain TLR2 agonists. (C) 2010 Elsevier Ltd. All rights reserved.
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