Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 16, Pages 4805-4807Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.06.111
Keywords
DOTA; Copper-free; Click chemistry; Peptides; Chelators; Bioconjugates
Categories
Funding
- University of Iowa Holden Comprehensive Cancer Center
- American Cancer Society
- Iowa Cardiovascular Interdisciplinary Research Fellowship [HL07121]
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Attachment of DOTA to a novel monofluoro-cyclooctyne facilitates bioconjugation to an azide-modified peptide via Cu-free click chemistry. The resulting conjugate was radiolabeled with (111)In to afford a potential targeted molecular imaging agent with high specific activity and an excellent radiochemical purity. (C) 2010 Elsevier Ltd. All rights reserved.
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