Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 1, Pages 42-47Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.11.041
Keywords
2,6-Dithienyl-4-furyl pyridine; Topoisomerase I and II inhibitor; Cytotoxicity; Antitumor agents; Docking study
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Funding
- Korean Government (MOEHRD, Basic Research Promotion Fund) [KRF-2008-313-E00762]
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For the development of novel antitumor agents, 2,6-dithienyl-4-furyl pyridine derivatives were prepared and evaluated for their topoisomerase I and II inhibitory activity as well as cytotoxicity against several human cancer cell lines. Among the 21 prepared compounds, compound 24 exhibited strong topoisomerase I inhibitory activity. In addition, a docking study with topoisomerase I and compound 24 was performed. (C) 2009 Elsevier Ltd. All rights reserved.
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