Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 35, Issue 8, Pages 1233-1236Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/jcbfm.2015.100
Keywords
ATP; brain injury; migration; process protrusion; Rac1
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Funding
- Max Planck Society
- DFG Research Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB)
- Niedersachsen-Research Network on Neuroinfectiology (N-RENNT) of the Ministry of Science and Culture of Lower Saxony
- [SFB TRR 43]
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Traumatic brain injury causes progressive brain atrophy and cognitive decline. Surprisingly, an early treatment with erythropoietin (EPO) prevents these consequences of secondary neurodegeneration, but the mechanisms have remained obscure. Here we show by advanced imaging and innovative analytical tools that recombinant human EPO, a clinically established and neuroprotective growth factor, dampens microglial activity, as visualized also in vivo by a strongly attenuated injury-induced cellular motility.
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