Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 9, Pages 2718-2721Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.03.079
Keywords
Sulfated gold nanoparticles; gp120 interaction; Surface plasmon resonance; HIV neutralization assays; Anti-HIV systems
Categories
Funding
- MICINN [CTQ2008-04638]
- EU [LSHP-CT-2003-503558]
- Red de Investigacion en SIDA [RIS ISCIII-RETIC RD06/0006]
- Network of Excellence EUROPRISE
- Fondo de Investigacion Sanitaria FIS [PI080752]
- EC
- AVIP and NGIN consortia
- Bill and Melinda Gates GHRC
- EMPRO
- MICINN
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Gold nanoparticles coated with multiple copies of an amphiphilic sulfate-ended ligand are able to bind the HIV envelope glycoprotein gp120 as measured by surface plasmon resonance (SPR) and inhibit in vitro the HIV infection of T-cells at nanomolar concentrations. A 50% density of sulfated ligands on similar to 2 nm nanoparticles (the other ligands being inert glucose derivatives) is enough to achieve high anti-HIV activities. This result opens up the possibility of tailoring both sulfated ligands and other anti-HIV molecules on the same gold cluster, thus contributing to the development of non-cocktail based multifunctional anti-HIV systems. (C) 2010 Elsevier Ltd. All rights reserved.
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