Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 8, Pages 2421-2424Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.03.037
Keywords
Manganese; SOD mimic; Pentaaza; Macrocycle
Categories
Funding
- Ministry of Land, Transport and Maritime Affairs, Republic of Korea
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New manganese(II) complexes of substituted pyridino pentaaza macrocyclic ligands were prepared. The amino-, carboxy-, or other functional groups were placed in the vicinity of the axial position of the metal complex. Their SOD-like activity was determined by cytochrome c assay and compared with one another. The activities of pyridine analogs (12a-b and 13) and m-substituted analogs (12c and 12j) were similar and significantly better than that of the standard compound M-40403. The most potent compound was an o-aminobenzoyl derivative 12i, while the o-carboxybenzoyl analog 12d was the lowest active compound. (C) 2010 Elsevier Ltd. All rights reserved.
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