Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 14, Pages 3791-3794Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.04.032
Keywords
RNAi; miRNA; MicroRNA; Gene promoter; Antigene; Noncoding RNA; Duplex RNA; Hybridization
Categories
Funding
- National Institutes of Health [GM 77253, CA 129632]
- The Robert A. Welch Foundation [I-1244]
- NIH
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Synthetic small duplex RNAs that are complementary to gene promoters can activate or inhibit target gene expression. The potency and robustness of gene modulation by these RNAs suggests that natural mechanisms may exist to facilitate recognition of sequences within gene promoters by endogenous small RNAs. Here, we describe computational methods for identifying potential miRNA target sites within gene promoters. These methods will facilitate investigations of whether miRNAs interact with sequences outside of 3'-untranslated regions and suggest new targets for the design of synthetic modulators of gene expression. (C) 2009 Elsevier Ltd. All rights reserved.
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