Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 19, Pages 5636-5639Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.08.051
Keywords
Translocator protein (TSPO); [C-11]PBR28; Radiosynthesis; Positron emission tomography (PET); Traumatic brain injury (TBI); Brain imaging
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Funding
- Indiana Genomics Initiative (INGEN) of Indiana University
- NIH [5R01AG019771, 3P30AG010133-18S1, 5P50NS052606]
- Indiana Economic Development Corporation [IEDC 87884]
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Fully automated synthesis and initial PET evaluation of a TSPO radioligand, [C-11]PBR28 (N-(2[C-11]methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamide), are reported. These results facilitate the potential preclinical and clinical PET studies of [C-11]PBR28 in animals and humans. (C) 2009 Elsevier Ltd. All rights reserved.
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