Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 22, Pages 6298-6302Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.09.105
Keywords
Id proteins; Protein domain recognition; Helix-loop-helix; Peptide dimerization; Peptide mimic; Solid-phase peptide synthesis; Smooth muscle cell
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Funding
- DFG [CA296/1-3]
- DAAD
- EU [LSHM-CT-2006-037498]
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Modulation of smooth muscle cells to a proliferating and migrating phenotype with downregulated alpha-actin expression is observed upon vascular lesion formation. The Id proteins (inhibitors of cell differentiation) play a role in the development of this phenotype. In contrast, synthetic peptides based on a conserved 11-residue Id sequence trigger the switch to a contractile phenotype that shows reduced cell growth and migration, increased expression of alpha-actin and decreased Id protein levels. (C) 2009 Elsevier Ltd. All rights reserved.
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