Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 14, Pages 3804-3807Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.04.028
Keywords
ATP; Azide; Alkyne; Alkene; Phosphorylation; Kinase
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Funding
- Biotechnology and Biological Sciences Research Council
- Cancer Research UK
- BBSRC [BB/D524208/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D524208/1] Funding Source: researchfish
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We hereby present a simple yet novel chemical synthesis of a family of gamma-modified ATPs bearing functional groups on the gamma-phosphate that are amenable to further derivatization by highly selective chemical manipulations (e.g., click chemistry, Staudinger ligations). A preliminary screen of these compounds as phosphate donors with a typical wild type protein kinase (cdk2) and one of its known substrates p27(kip1) is also presented. (C) 2009 Elsevier Ltd. All rights reserved.
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