Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 19, Pages 5560-5564Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.08.045
Keywords
Oral absorption; Permeability; Efficiency; log D; Molecular weight; Molecular properties; Molecular descriptors; Clearance; Lipophilicity; Ligand efficiency; Ligand-lipophilicity efficiency; Golden triangle; Metabolism-lipophilicity efficiency
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The Golden Triangle is a visualization tool developed from in vitro permeability, in vitro clearance and computational data designed to aid medicinal chemists in achieving metabolically stable, permeable and potent drug candidates. Classifying compounds as permeable and stable and plotting molecular weight (MW) versus octanol: buffer (pH 7.4) distribution coefficients (log D) or estimated octanol: buffer (pH 7.4) distribution coefficients (elog D) reveals useful trends. Analysis of at least two orthogonal trends, such as permeability and clearance, can be extremely effective in balancing and optimizing multiple properties. In addition, molecular weight and log D impact potency-efficiency calculations, allowing potency, clearance and permeability to be optimized simultaneously. (C) 2009 Elsevier Ltd. All rights reserved.
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