[18F]FEAC and [18F]FEDAC: Two novel positron emission tomography ligands for peripheral-type benzodiazepine receptor in the brain

[F-18]FEAC ([F-18]4a) and [F-18]FEDAC ([F-18]4b) were developed as two novel positron emission tomography (PET) ligands for peripheral-type benzodiazepine receptor (PBR). [F-18]4a and [F-18]4b were synthesized by fluoroethylation of precursors 8a and 8b with [ 18F] FCH2CH2Br ([ 18F] 9), respectively. Small-animal PET scan for a neuroinflammatory rat model showed that the two radioligands had high uptakes of radioactivity in the kainic acid-infused striatum, a brain region where PBR density was increased. (C) 2009 Elsevier Ltd. All rights reserved.