4.5 Article

Substrate specificity of N-acetylhexosamine kinase towards N-acetylgalactosamine derivatives

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 18, Pages 5433-5435

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.07.104

Keywords

Kinase; Phosphorylation; Specificity

Funding

  1. National Cancer Institute [R01 CA118208]
  2. NSF [CHE-0616892]
  3. China Scholarship Council
  4. Ohio BioProducts Innovation Center

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We report herein a bacterial N-acetylhexosamine kinase, NahK, with broad substrate specificity towards structurally modified GalNAc analogues, and the production of a GalNAc-1-phosphate library using this kinase. (C) 2009 Published by Elsevier Ltd.

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