Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 10, Pages 2880-2883Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.03.064
Keywords
Signal peptidase; Antibiotics; Peptides; Structure-activity relationship
Categories
Funding
- IWT [SBO-050146]
- National Fund for Scientific Research Vlaanderen (FWO Vlaanderen)
Ask authors/readers for more resources
Bacterial type I signal peptidase is a potential target for the development of novel antibacterial agents. In this study we demonstrate that a substrate based peptide aldehyde inhibits signal peptidases with a lower IC50 value than the lipopeptides described to date. The length of the core lipopeptide could be reduced by removing several amino acids from both termini. Conversion of this peptide to an aldehyde resulted in a molecule with an IC50 value of 0.09 mu M when tested against Saccharomyces aureus SPase I, SpsB. (C) 2009 Published by Elsevier Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available