Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 19, Pages 5539-5542Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.08.057
Keywords
Immunosuppressive; Indoloisoquinoline; Phosphazine; Condensation
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Funding
- Department of Chemistry at Iowa State University
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Dihydroindolo[2,1-a]isoquinolines were synthesized from tetrahydroisoquinolines and alpha-fluoroaldehydes by a novel two-step procedure. These compounds exhibited significant immunosuppressive activity against IL-2, IL-10 and IFN-gamma. (C) 2009 Elsevier Ltd. All rights reserved.
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