Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 7, Pages 2029-2032Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.02.027
Keywords
Monomycolyl glycerol; Adjuvant; Vaccine; Tuberculosis; Ag85B-ESAT-6
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Funding
- European Commission [LSHPCT2003-503367]
- Royal Society Wolfson Research Merit Award
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A simplified C-32 monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C32 MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB). (C) 2009 Elsevier Ltd. All rights reserved.
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