Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 16, Pages 4570-4573Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.06.098
Keywords
Breast cancer; Hydroxycoumarin; Pyranocoumarin; Antiproliferative activity; New substituted 5-hydroxycoumarin; Against breast cancer cell lines
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Funding
- National Natural Science Foundation of China [20671036, 2007A010500008, 2008B010800030]
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A library of novel 5-hydroxycoumarin and pyranocoumarin derivatives was constructed via silica sulfuric acid-catalyzed pechmann reaction and Pd(0)-catalyzed suzuki coupling in tandem, and their antiproliferative activities against breast cancer cells MCF-7 and MDA-MB-231 were evaluated. The results showed that compounds such as 6b, 6d, 6h, and 6k possess significant antiproliferative activity against MCF-7 cell line with the IC50 values of 7.2, 5.3, 3.3, and 6.5 mu M, respectively. (C) 2009 Elsevier Ltd. All rights reserved.
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