Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 2, Pages 524-527Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.11.021
Keywords
Antibacterial; Alkoxybenzamide; FtsZ; 3-Methoxybenzamide; Antibacterial efficiency
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Funding
- East Hill Management (Boston, USA)
- UK Biotechnology and Biological Sciences Research Council
- UK Department of Trade and Industry
- PCT/GB2007/001012
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3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds. (C) 2008 Elsevier Ltd. All rights reserved.
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