Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 19, Pages 5569-5572Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.08.047
Keywords
Click chemistry; Arthritis; Multicomponent; Michael reaction; Baylis Hillman
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Funding
- CSIR, New Delhi
- DST, New Delhi
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Solvent free multicomponent reaction of Baylis Hillman acetate, TMS azide and arylnitrile to produce 1,5-disubstituted tetrazole is described. Some of these tetrazoles are found to be potential TNF-alpha inhibitors. (C) 2009 Elsevier Ltd. All rights reserved.
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